Signed to EMI, although the band had strong initial success, it eventually disbanded. In 2000, Joe recorded his debut solo CD, A New Day Yesterday, produced by the legendary Tom Dowd (Aretha Franklin, Ray Charles, Eric Clapton, Rod Stewart, John Coltrane). The memorable melodies and potent guitar work of A New Day Yesterday brought to mind the classic blues-based rock of Cream, Lynyrd Skynyrd, the Jeff Beck Group, and the Allman Brothers Band. Upon returning from the road in 2002, Bonamassa hooked up with Clif Magness (Avril Lavigne) to record the muscular and sweeping studio disc So, It's Like That, which hit ..1 on the Billboard Blues Chart multiple times.
To celebrate 2003 Year of the Blues, Bonamassa released Blues Deluxe, featuring nine cover versions of blues classics along with three originals. Around this time, Joe became involved with Blues in the Schools, a program developed by the Blues Foundation to help perpetuate the heritage and legacy of blues music. The lectures take teenage students on a journey, tracing the evolution of blues music, from its birth among the field workers of the Delta during the late 1800s up to the present day. The lectures are followed by a live performance by Bonamassa.
Bonamassas next CD, Had To Cry Today, continued where Blues Deluxe left off. Mixing original and classic blues, the CD incorporates influences of Chicago, Delta and British blues into something electrifying and wholly unique. In the summer of 2005, Bonamassa was personally asked by BB King to open for his landmark 80th Birthday Celebration Tour, and a few months later in January 2006, Bonamassa, in recognition of efforts in promoting blues music, was nominated as the youngest member of The Blues Foundation committee board. Bonamassas latest CD, You and Me, is scheduled for a June 6, 2006 release. The new CD marks the debut collaboration of Bonamassa and producer Kevin Shirley (Led Zeppelin, The Black Crowes, Aerosmith, Joe Satriani).
A powerful fusion of the big rock sound and swampy blues, You and Me gets much of its inspiration from such masters as Peter Green, Jeff Beck, Eric Clapton and John Lee Hooker. Bonamassa makes his home in Los Angeles.